Preparation, Characterization, In-Vitro Drug Release and Kinetics Studies Canagliflozin Polymeric Nanopartciles

Abiramee Ravi, Assistant Professor, Sri Shakthi Institute of Engineering and Technology, Coimbatore (TN)
2021 Journal of Medical Science And clinical Research  
Nanosuspension is one of the most promising approaches for the enhancement of oral bio-availability of poorly soluble drugs. In this current research work, 13 different formulations of surfactant-stabilized nanosuspension of canagliflozin polymeric nanoparticles were developed and optimized based on average particle size distribution, entrapment efficiency, and zeta potential. In-vitro drug release and kinetics experiments were also investigated. The nanoparticle formulation CGF-12 was found
more » ... h optimum results in particle size distribution and zeta potential analysis. The %EE of drug in the prepared nanosuspension was in the range of 49.5 ± 0.70 to 100 ± 2. In in-vitro drug release studies, CGF-12 formulation showed maximum drug release of 100% in distilled water within 3 hours, 93% in HCl media at the end of 8 hours and reached 100% in phosphate buffer media within 2 hours. Hence, the formulated canagliflozin polymeric nanoparticles are good choice to improve physicochemical properties of the drug and these formulations improve canagliflozin drug efficacy.
doi:10.18535/jmscr/v9i6.35 fatcat:7rorrllqirbifmou66u64wfx7i