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Bulgarian Chemical Communications
Dedicated to Acad. Bogdan Kurtev on the occasion of his 100 th birth anniversary trans-5-Aminomethyl-1-benzyl-6-phenylpiperidin-2-one (2) was prepared in high yield via Mitsunobu methodology and acylated by means of N-protected α-amino acids glycine, L-tryptophan, L-phenylalanine and L-alanine to give new piperidinones with a peptide bond in the side chain to the piperidinone cycle. N-Deprotection was carried out and the side chain of the tryptophan derivative 4 was elongated to yield productsfatcat:fj7lux2bnnashb4h7tyv75j6ju