What factors predispose patients to acute respiratory distress syndrome? [chapter]

Yewande Odeyemi, Alice Gallo De Moraes, Ognjen Gajic
2020 Evidence-Based Practice of Critical Care  
Acute respiratory distress syndrome (ARDS) is a common complication of critical illness or injury associated with significant morbidity and mortality. The pathogenesis of ARDS involves mechanical and inflammatory injury to the lungs that causes marked derangement in alveolar-capillary permeability and the passage of protein-rich edema fluid into the air spaces. 1,2 ARDS usually occurs in a context of uncontrolled response to local or systemic inflammation and most recently two endotypes of
more » ... o endotypes of ARDS-namely, hyperinflammatory and hypoinflammatory-have been identified with different therapeutic responses and prognoses. 3, 4 The clinical pathogenesis is often multifactorial, with complex interaction of risk factors and risk modifiers (Fig. 15.1) .
doi:10.1016/b978-0-323-64068-8.00024-9 fatcat:tv4vf23cpzg7pi33xlj4ny6t3i