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Trends in Genetics
Over the past decade, the ubiquity of copy number variants (CNVs, the gain or loss of genomic material) in the genomes of healthy humans has become apparent. Although some of these variants are associated with disorders, a handful of studies documented an adaptive advantage conferred by CNVs. In this review, we propose that CNVs are substrates for human evolution and adaptation. We discuss the possible mechanisms and evolutionary processes in which CNVs are selected, outline the currentdoi:10.1016/j.tig.2012.03.002 pmid:22483647 pmcid:PMC3533238 fatcat:mz2thiojbffexlwqxspgkxnmam