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Two young dogs (a 4-month-old male French Bulldog, and a 4-month-old male Akita) presented with severe systemic pain involving bone resorption and multiple fractures. Other diseases characterized by bone fragility were excluded by clinical examinations, and so the dogs were provisionally diagnosed with osteogenesis imperfecta. In both dogs, the systemic pain resolved within 1 week after the start of diagnostic treatment with oral bisphosphonate (0.5-1.0 mg/kg), and bone unions were achieved indoi:10.2327/jjvas.48.15 fatcat:jrc7al6vhffdpj4jmxnkprqcbu