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In March 2010, the Dagstuhl Seminar 10102 explored the grand challenges confronting research and practice in the domain of discrete event logistics systems. This Executive Summary describes the process of the seminar and discusses the key conclusions regarding grand challenges for research and practice. Abstracts of the presentations given during the seminar are put together in the online proceedings.fatcat:fq7flevjebfzxgn7nlmpbszc2q