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RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis
2019
PLoS ONE
The early steps in the pathophysiology of celiac disease (CD) leading to loss of tolerance to gluten are poorly described. Our aim was to use RNA sequencing of duodenal biopsies in patients with active CD, CD in remission, and non-CD controls to gain insight into CD pathophysiology, identify additional genetic signatures linked to CD, and possibly uncover targets for future therapeutic agents.
doi:10.1371/journal.pone.0215132
pmid:30998704
pmcid:PMC6472737
fatcat:boca54brpbfglnqwybwosygwyq