Longer Duration of Untreated Psychosis is Associated with Poorer Outcomes for Patients with Delusional Infestation

D Romanov, P Lepping, A Bewley, M Huber, R Freudenmann, A Lvov, S Squire, E Noorthoorn
2018 Acta Dermato-Venereologica  
1 We examined the association between the duration of untreated psychosis and outcome for patients with delusional infestation. This multi-centre international study included consecutive 211 patients. Illness severity was evaluated at first presentation and outcome was measured with the Clinical Global Impression scale (CGI) at baseline and follow-up. A regression analysis showed a clear clinical and statistically significant association between shorter duration of untreated psychosis and
more » ... outcome at follow-up. Patients with a duration of untreated psychosis of less than one year showed a CGI-S change from 5.37 to 2.07; those with a duration of untreated psychosis of 1-5 years a change from 5.48 to 2.59, and those with a duration of untreated psychosis of > 5 years a change from 5.59 to 3.37. This difference of 1.1 CGI points between the groups resembles a clinically relevant difference in patient outcome. Our results suggest that longer duration of untreated psychosis in patients with delusional infestation is associated with significantly less favour able clinical outcomes.
doi:10.2340/00015555-2888 pmid:29362814 fatcat:sk7g2azv5jbcldqsbt5rj2ojvm