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Faculty of 1000 evaluation for Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models [dataset]

Dan Kaufman, Andres Wiernik
2011 F1000 - Post-publication peer review of the biomedical literature   unpublished

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Hematopoietic stem cells (HSCs) are used in transplantation therapy to reconstitute the hematopoietic system. Human cord blood (hCB) transplantation has emerged as an attractive alternative treatment option when traditional HSC sources are unavailable, however, the absolute number of hCB HSCs transplanted is significantly lower than bone marrow or mobilized peripheral blood stem cells (MPBSCs). We previously demonstrated that dimethyl-prostaglandin E2 (dmPGE2) increased HSCs in vertebrate
more » ... . Here, we describe preclinical analyses of the therapeutic potential of dmPGE2-treatment using human and non-human primate HSCs. dmPGE2 significantly increased total human hematopoietic colony formation in vitro and enhanced engraftment of unfractionated and CD34 + hCB following xenotransplantation. In non-human primate autologous transplantation, dmPGE2-treated CD34 + MPBSCs showed stable multilineage engraftment over one year post-infusion. Together, our analyses indicated that dmPGE2 mediates
doi:10.3410/f.10490956.11745055 fatcat:2pqymo2iinbsnabjgy6xclzrnq
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Dan Kaufman, Andres Wiernik. "Faculty of 1000 evaluation for Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models." F1000 - Post-publication peer review of the biomedical literature (2011)