66: Excellent Engraftment and Rapid Immune Recovery in Haploidentical Stem Cell Transplantation Using CD3/CD19 Depleted Peripheral Stem Cell Grafts After Reduced Intensity Conditioning

P. Bader, J. Soerensen, U. Koehl, H. Kreyenberg, A. Jarisch, G. Weber, G. Sach, A. Willasch, S. Kuci, T. Tonn, R. Esser, T. Klingebiel
2008 Biology of Blood and Marrow Transplantation  
amphotericin B therapy (p 5 0.08) were not statistically significant. There was a slight trend towards a higher rate of chronic GVHD in patients with ES (p 5 0.11). However, after a median follow up of 9.5 years overall survival (48% with ES vs. 50% without ES; p 5 0.53) and transplant related mortality (21% vs. 17%; p 5 0.65) did not differ between the two groups. Prednisolone (2 mg/kg/d) was administered in 62% of children with ES. Conclusion: ES presenting with fever, rash, weight gain and
more » ... , weight gain and pulmonary symptoms should be recognized as a frequent complication of allogeneic HSCT after myeloablative conditioning in children. Treatment with G-CSF and a high nucleated cell count of the graft predisposed for the development of ES in this study. Overall survival and transplant related mortality in this cohort were not affected by the occurrence of ES, possibly due to therapeutic intervention with prednisolone in a high proportion of patients.
doi:10.1016/j.bbmt.2007.12.074 fatcat:genqeaj2xzfu3osqiqdupfipiq