In vitroantimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria

Akinobu Ito, Naoki Kohira, Samuel K. Bouchillon, Joshua West, Stephen Rittenhouse, Helio S. Sader, Paul R. Rhomberg, Ronald N. Jones, Hidenori Yoshizawa, Rio Nakamura, Masakatsu Tsuji, Yoshinori Yamano
2015 Journal of Antimicrobial Chemotherapy  
Objectives: S-649266 is a parenteral siderophore cephalosporin antibiotic with a catechol moiety on its side chain. The in vitro antimicrobial activity of S-649266 against non-fermenting Gram-negative bacteria was evaluated and compared with the activities of meropenem, levofloxacin, cefepime, ceftazidime and piperacillin/ tazobactam. Methods: MIC values of S-649266 were determined in Mueller -Hinton broth or Iso-Sensitest broth supplemented with apo-transferrin. Results: S-649266 showed potent
more » ... 49266 showed potent in vitro activity against the non-fermenting Gram-negative bacteria Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, including MDR strains such as carbapenemresistant A. baumannii and metallo-b-lactamase-producing P. aeruginosa. MIC 90 s of S-649266 for A. baumannii, P. aeruginosa and S. maltophilia were 2, 1 and 0.5 mg/L, respectively, whereas MIC 90 s of meropenem were .16 mg/L. S-649266 showed potent in vitro activities against A. baumannii producing carbapenemases such as OXA-type b-lactamases, and P. aeruginosa producing metallo-b-lactamases such as IMP type and VIM type. MIC 90 values for these A. baumannii strains and P. aeruginosa strains were 8 and 4 mg/L, respectively. Conclusions: S-649266 is a novel antibiotic with potent in vitro activity against a range of non-fermenting Gram-negative bacteria, including MDR strains.
doi:10.1093/jac/dkv402 pmid:26645269 fatcat:omyi7d4k7beqrm4vcct7hyr6ge