A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Rho-kinase mediates the anorexigenic action of melanocortin by suppressing AMPK
[article]
2019
bioRxiv
pre-print
Objective: Melanocortin action is essential for the maintenance of energy homeostasis. However, knowledge of the signaling mechanism(s) that mediates the effect of melanocortin remains incomplete. Methods: ROCK1 is a key regulator of energy balance in the hypothalamus. To explore the role of ROCK1 in the anorexigenic action of melanocortin, we deleted ROCK1 in MC4R neurons in mice. Next, we studied the metabolic effects of MC4R neuron-specific ROCK1-deficiency and following treatment with
doi:10.1101/677880
fatcat:wzqs3k7dmvcdfkgp5cxvp4zb24