Untersuchung der Seroprävalenz von Antikörpern gegen Parvovirus B19 in der Bevölkerung der Bundesrepublik Deutschland

Christoph Michael Röhrer
Parvovirus B19 infection is associated with a wide spectrum of diseases. Besides acute infection resulting in anemia and erythema infectiosum (fifth disease), a childhood disease, acute symmetrical polyarthropathy or arthritis in children and adults were reported as clinical manifestations. Depending on the host�s hematologic status, B19 infection may be associated with hematopoetic disorders like aplastic crisis, thrombocytopenia and pancytopenia. In rare cases the patients may develop
more » ... may develop hepatitis, myocarditis, myositis, vasculitis, encephalitis and autoimmune phenomena. Dependent on the week of gestation B19 infection can be life-threatening for the fetus as it might cause hydrops fetalis and fetal death. Parvovirus B19 is restricted to human hosts and transmitted by respiratory aerosol spread from individuals with acute infection. The majority of infections occur during childhood and adolescence. Data on the seroprevalence of parvovirus B19 are not available for Germany. Detailed epidemiological data about parvovirus B19 infection are essential for both, the medical care management of an acute infection in pregnant women and the protective legislation during pregnancy and maternity prohibiting employment of pregnant women if occupational activities endanger the health of either the mother-to-be or the fetus. I tested a representative panel of sera collected from adults in former Eastern and Western Germany during the German National Health Survey adolescents for the presence of IgG against parvovirus B19. These data offer new insights into the seroepidemiology of the infection.
doi:10.5283/epub.12265 fatcat:qtqcopb6xvhu3bbbw3p4zzf4du