A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif

Jan Cools, Nicole Mentens, Peter Marynen
2001 FEBS Letters  
We recently cloned the CHIC2 gene (previously BTL) by virtue of its involvement in a chromosomal translocation t(4;12)(q11;p13) occurring in acute myeloid leukemias. In this study we show that CHIC2 is a member of a highly conserved family of proteins characterized by the presence of a striking cysteine-rich hydrophobic (CHIC) motif. Our data illustrate that cysteines in this central CHIC motif are palmitoylated and that CHIC2 is associated with vesicular structures and the plasma membrane. The
more » ... CHIC proteins thus resemble the cysteine string proteins, which function in regulated exocytosis. ß
doi:10.1016/s0014-5793(01)02240-2 pmid:11257495 fatcat:5a6jryzir5drdibk7yezfpf6iu