Pharmacokinetics of Sufentanil in the Elderly Surgical Patient

R. S. MATTEO, A. E. SCHWARTZ, E. ORNSTEIN, W. L. YOUNG, W. CHANG
1991 Survey of Anesthesiology  
The effect of age on the distribution and elimination of sufentanil was studied in seven elderly (77 +-5 yr, mean +--SD) and seven younger (41 +--15 yr) neurosurgical patients. Following a single IV bolus of sufentanil 2 Izg " kg-t multiple arterial samples were obtained at timed intervals and plasma concentrations of sttfentanil were measured by radioimmunoassay. Pharmacokinetic variables were calculated from the derived compartmental models. The initial volume of distribution was
more » ... on was significantly smaller in the elderly patients (310 +-109 ml" kg-t vs 491 +-112 ml. kg-t mean ++. SD). Elhnination half-lives, plasma clearances, and total volumes of distribution were similar for elderly and younger subjects. SLr of seven elderly patients required administration of nalo~rone at the termination of surgery to achieve an adequate rate of ventilation (> eight breaths, rain -t ) while only one younger patient required antagonism of ventila. tory depression. The attthors believe that age-related differences in the action of sufentanil cannot be accounted for by the observed differences in the initial volume of distribution. It is concluded that alterations in pharmacodyamics appear to be of greater importance in the prolonged opioid effect seen in the elderly. L' effet de I'dge sur la distribution et I'Elimination du sufentanil a dtd ~tudi~ chez septpatients dg~s (77 +-5 arts, moyenne +-SD) et sept patients moins dg~s (41 +--15 arts) devant subir des
doi:10.1097/00132586-199108000-00038 fatcat:idft7olelzfarbsas3fpnkeoia