Computational algorithms to predict Gene Ontology annotations

Pietro Pinoli, Davide Chicco, Marco Masseroli
2015 BMC Bioinformatics  
Gene function annotations, which are associations between a gene and a term of a controlled vocabulary describing gene functional features, are of paramount importance in modern biology. Datasets of these annotations, such as the ones provided by the Gene Ontology Consortium, are used to design novel biological experiments and interpret their results. Despite their importance, these sources of information have some known issues. They are incomplete, since biological knowledge is far from being
more » ... efinitive and it rapidly evolves, and some erroneous annotations may be present. Since the curation process of novel annotations is a costly procedure, both in economical and time terms, computational tools that can reliably predict likely annotations, and thus quicken the discovery of new gene annotations, are very useful.
doi:10.1186/1471-2105-16-s6-s4 pmid:25916950 pmcid:PMC4416163 fatcat:wr6znhkvr5cdzhzeu6w2mrl25u