Temporal Changes in Invasive Group B Streptococcus Serotypes: Implications for Vaccine Development

Ziyaad Dangor, Clare L. Cutland, Alane Izu, Gaurav Kwatra, Siobhan Trenor, Sanjay G. Lala, Shabir A. Madhi, Adam J. Ratner
2016 PLoS ONE  
Methods From 2005 to 2014, infants less than 90 days of age with invasive GBS disease were identified through sentinel laboratory and hospital admission surveillance at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa. Results We identified 820 cases of invasive GBS disease, including 55% among newborns <7 days age (i.e. early-onset disease; EOD). The overall incidence (per 1,000 live births) of invasive GBS disease was 2.59 (95% CI: 2.42-2.77), including 1.41 (95% CI:
more » ... for EOD and 1.18 (95% CI: 1.06-1.30) in infants 7-89 days age (late-onset disease). Year-on-year, from 2005 to 2014, we observed a 9.4% increase in incidence of serotype Ia invasive disease (RR: 1.09; 95% CI: 1.04-1.15; p<0.001), and a 7.4% decline in serotype III invasive disease (RR: 0.93; 95% CI: 0.90-0.96; p<0.001). Overall, serotypes Ia (28.2%), III (55.4%) and V (7.9%) were the commonest disease causing serotypes. Conclusions The incidence of invasive GBS disease has remained persistently high in our setting, with some changes in serotype distribution, albeit mainly involving the same group of dominant serotypes.
doi:10.1371/journal.pone.0169101 pmid:28036363 pmcid:PMC5201280 fatcat:bejs7rfxnjep5h5oe764vdjxa4