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Interaction of Norfloxacin with Super-Coiled DNA
2003
Bulletin of the Korean Chemical Society (Print)
Norfloxacin, that inhibits the action of topoisomerase II, binds to wide variety of DNA. The binding mode of this drug to double-and super-coiled DNA (ds-and scDNA) is compared in this study by various spectroscopic methods, including absorption, fluorescence, and circular dichroism(CD) spectroscopy. Hypochromism in the absorption band, negative and positive induced CD bands (respectively in 240-260 nm and 270-300 nm region) are apparent for the norfloxacin that bound to both the dsDNA and
doi:10.5012/bkcs.2003.24.5.579
fatcat:ywy3qdmsinba7jiflkt57ph3ly