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DNA Methylation in Benign Breast Epithelium in Relation to Age and Breast Cancer Risk
2008
Cancer Epidemiology, Biomarkers and Prevention
Many established breast cancer risk factors are related to the timing and duration of exposure to reproductive hormones, which are known to drive breast epithelial cell proliferation. The epigenetic molecular clock hypothesis suggests that CpG island methylation records the cell division history of benign epithelium. In proliferative epithelium, such as breast, this may provide an individualized cell-based measure of cancer risk. Methods: Methylation of cyclin D2, APC, HIN1, RASSF1A, and RAR-b2
doi:10.1158/1055-9965.epi-07-2582
pmid:18483325
fatcat:kp4dpd2al5hyvcirji6t67oypu