3P020 Computational study on the intramolecular signaling mechanism of histamine receptor(01B. Protein: Structure & Function,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))
3P020 ヒスタミンH1 受容体の分子内情報伝達機構に関する理論的研究(01B. 蛋白質:構造機能相関,ポスター,第52回日本生物物理学会年会(2014年度))

Yuko Ishii, Takakazu Ishikura, Takahisa Yamato
2014 Seibutsu Butsuri  
Technology, Kinki University) c-Myb protein is a transcription factor connected with proliferation and differentiation of hematopoietic cells. In this study, wild-type (WT) c-Myb with a cavity and a mutant-type (V103L) with a vanishingly small cavity were studied by molecular dynamics simulation at 1 and 3k bar for 200 ns in order to establish the relationship among the cavity, the compression, and conformational changes. We calculated the root mean square deviation (RMSD), the protein volume
more » ... he protein volume (probe size 1.1Å), cavity volume, and a difference map (DM) of c-Myb under pressure at 1 and 3k bar from the trajectories. From these results, we conclude that there must be a relationship between the cavity and characteristic conformational changes. 3P020 ヒスタミン H 1 受容体の分子内情報伝達機構に関する理論的 研究 Computational study on the intramolecular signaling mechanism of histamine receptor Yuko Ishii, Takakazu Ishikura, Takahisa Yamato (Grad. Sch. Sci., Nagoya Univ.)
doi:10.2142/biophys.54.s252_2 fatcat:q4uqoudxxna77k7d5mwbxx3bja