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EP2 receptor mediates PGE2-induced cystogenesis of human renal epithelial cells
2007
AJP - Renal Physiology
polycystic kidney disease (ADPKD) is characterized by formation of cysts from tubular epithelial cells. Previous studies indicate that secretion of prostaglandin E 2 (PGE2) into cyst fluid and production of cAMP underlie cyst expansion. However, the mechanism by which PGE 2 directly stimulates cAMP formation and modulates cystogenesis is still unclear, because the particular E-prostanoid (EP) receptor mediating the PGE2 effect has not been characterized. Our goal is to define the PGE 2 receptor
doi:10.1152/ajprenal.00036.2007
pmid:17728378
fatcat:2qrb73xu2vfc7ob75yetk2qi4q