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Detection and confirmation of the ring-opened carboxylic acid metabolite of a new synthetic opioid furanylfentanyl
Purpose Recently, the opioid epidemic has become a serious problem, particularly in North America and Europe. The aim of this study was to clarifyQuery the metabolic fate of a new synthetic opioid furanylfentanyl. Methods The metabolism of furanylfentanyl was investigated by incubating fresh human hepatocytes with 10 µM furanylfentanyl at 37 °C for 48 h in an atmosphere of 5% CO 2 . After incubation, the culture medium was deproteinized and analyzed by liquid chromatography/mass spectrometry.doi:10.1007/s11419-020-00546-7 fatcat:vvz24d3a7ngglkkwuw2bhcb3vi