Application and validation of spatial mixture modelling for the joint detection-estimation of brain activity in fMRI

Thomas Vincent, Philippe Ciuciu, Jerome Idier
2007 IEEE Engineering in Medicine and Biology Society. Conference Proceedings  
Within-subject analysis in event-related functional Magnetic Resonance Imaging (fMRI) first relies on (i) a detection step to localize which parts of the brain are activated by a given stimulus type, and second on (ii) an estimation step to recover the temporal dynamics of the brain response. Recently, a Bayesian detection-estimation approach that jointly addresses (i)-(ii) has been proposed in [1] . This work is based on an independent mixture model (IMM) and provides both a spatial activity
more » ... p and an estimate of brain dynamics. In [2], we accounted for spatial correlation using a spatial mixture model (SMM) based on a binary Markov random field. Here, we assess the SMM robustness and flexibility on simulations which diverge from the priors and the generative BOLD model and further extend comparison between SMM and IMM on real fMRI data, focusing on a region of interest in the auditory cortex.
doi:10.1109/iembs.2007.4353518 pmid:18003184 fatcat:sitaer5ypbds5j3ye4igowjdt4