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The derivatives of 1,4-dihydropyridines are well known as calcium channel modulators for the treatment of cardiovascular disorders. Herein, three 1,4-dihydropyridines were synthesized through the condensation of an aldehyde, a β-ketoester, and ammonium acetate in ethanol with yields ranging from 23 to 59%. Their structures were confirmed by comparison HRMS, NMR spectral data with the literature. The acute oral toxicity study for the synthesized compounds revealed that all compounds were safe updoi:10.22144/ctu.jen.2018.028 fatcat:dxhwzcpnqbfcrddnm5kq52hlke