Synthesis and acute toxicity evaluation of Hantzsch 1,4-dihydropyridine derivatives

Nhu, H., Tram, N.T.T., Yen, T.H.
2018 Can Tho University Journal of Science  
The derivatives of 1,4-dihydropyridines are well known as calcium channel modulators for the treatment of cardiovascular disorders. Herein, three 1,4-dihydropyridines were synthesized through the condensation of an aldehyde, a β-ketoester, and ammonium acetate in ethanol with yields ranging from 23 to 59%. Their structures were confirmed by comparison HRMS, NMR spectral data with the literature. The acute oral toxicity study for the synthesized compounds revealed that all compounds were safe up
more » ... to 2,000 mg/kg, and no deaths of animals were recorded.
doi:10.22144/ctu.jen.2018.028 fatcat:dxhwzcpnqbfcrddnm5kq52hlke