A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
Synthesis and acute toxicity evaluation of Hantzsch 1,4-dihydropyridine derivatives
2018
Can Tho University Journal of Science
Preserved Fulltext
The derivatives of 1,4-dihydropyridines are well known as calcium channel modulators for the treatment of cardiovascular disorders. Herein, three 1,4-dihydropyridines were synthesized through the condensation of an aldehyde, a β-ketoester, and ammonium acetate in ethanol with yields ranging from 23 to 59%. Their structures were confirmed by comparison HRMS, NMR spectral data with the literature. The acute oral toxicity study for the synthesized compounds revealed that all compounds were safe up
doi:10.22144/ctu.jen.2018.028
fatcat:dxhwzcpnqbfcrddnm5kq52hlke