Formal Methods for Checking the Consistency of Biological Models [chapter]

Allan Clark, Vashti Galpin, Stephen Gilmore, Maria Luisa Guerriero, Jane Hillston
2011 Advances in Experimental Medicine and Biology  
Formal modelling approaches such as process algebras and Petri nets seek to provide insight into biological processes by using both symbolic and numerical methods to reveal the dynamics of the process under study. These formal approaches differ from classical methods of investigating the dynamics of the process through numerical integration of ODEs because they additionally provide alternative representations which are amenable to discrete-state analysis and logical reasoning. Backed by these
more » ... ditional analysis methods, formal modelling approaches have been able to identify errors in published and widely-cited biological models. This paper provides an introduction to these analysis methods, and explains the benefits which they can bring to ensuring the consistency of biological models.
doi:10.1007/978-1-4419-7210-1_27 pmid:22161346 fatcat:uie7z2ioprakpag3hvgvikhp5i