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A novel cell-based sensor detecting the activity of individual basic proprotein convertases
[article]
2018
bioRxiv
pre-print
ABSTRACTThe basic proprotein convertases (PCs) furin, PC1/3, PC2, PC5/6, PACE4, PC4, and PC7 are promising drug targets for human diseases. However, developing selective inhibitors remains challenging due to overlapping substrate recognition motifs and limited structural information. Classical drug screening approaches for basic PC inhibitors involve homogeneous biochemical assays using soluble recombinant enzymes combined with fluorogenic substrate peptides and do not accurately recapitulate
doi:10.1101/464032
fatcat:qjngca4np5as7l3yn6rn64n5ne