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Down syndrome (DS) is characterized by mental retardation and the development of Alzheimer's disease (AD). The reason for this development is not yet clear. Ts65Dn mice were used in this study. We collected their hippocampi and identified protein biomarkers using isobaric tags for relative and absolute quantitation (iTRAQ). We described the biochemical characteristics of proteins and explored their complicated network using GOA, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and networkdoi:10.2298/abs1403157z fatcat:evshcrddmbfhlo4eazkushx2gi