Fast-slow asymptotics for a Markov chain model of fast sodium current

Tomáš Starý, Vadim N. Biktashev
2017 Chaos  
We explore the feasibility of using fast-slow asymptotic to eliminate the computational stiffness of the discrete-state, continuous-time deterministic Markov chain models of ionic channels underlying cardiac excitability. We focus on a Markov chain model of the fast sodium current, and investigate its asymptotic behaviour with respect to small parameters identified in different ways.
doi:10.1063/1.5003013 pmid:28964114 fatcat:rcbujkva75frpiowryfhanz5ki