Ο ρόλος των γονιδιακών πολυμορφισμών των μεταλλοπρωτεινασών 1, 2, 3 και των αναστολέων τους στον πρόωρο τοκετό
Κωνσταντίνος Μ. Λαθουράς
2019
Preterm labor can lead to difficulties concerning not only the mother and family in general, but also the public health as a whole. Three percent of pregnancies are complicated by preterm prelabour rupture of membranes (PPROM). In addition, PPROM is deemed responsible for approximately one third of all preterm births. With PPROM, early delivery, a situation where prenatal and neonatal complications are common, can be foreseen. Hence, the healthcare professionals caring for this group of
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... has anopportunity to intervene in a manner that can improve perinatal outcome [73]. The role of MMPs and their inhibitors in relation to rupture of fetal membranes before physiological delivery has already been established. MMPs can be classified into six subgroups: collagenases, gelatinases, stormelysins, membrane-type, metalloelastases and 'other type' [17]. We chose one type of MMP from the first three aforementioned groups, in view of literature findings that point to those six subgroups being prominent in preterm labor. MMP1 is produced by mesenchymal cells such as fibroblasts and macrophages and is responsible for breaking down collagen type I–III. Collagen type III is present in amnion and mainly responsible for its integrity and durability. MMP 2 is responsible for breaking down fibronectin, and collagen type IV and VII. It is well established how fibronectin is related with respect to rupture of membranes. MMP3 is responsible for breaking down collagen type IV and fibronectin. Their increased concentration in this clinical setting proves their involvement in the loss of fetalmembraneintegrity [74 – 77]. It has been shown that increased concentrations of MMPs1, 2 and 9,coupled with simultaneous decrease in the concentration of TIMP1, can indeed be measured when fetal membranes breakdown prematurely [78]. Summary points• Extracellular matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are involved in the breakdown of fetal membranes before delivery• Our aim was to investigate the occurrence of any polymorphism o [...]
doi:10.26262/heal.auth.ir.301172
fatcat:6qnyp76nw5amhkngeyztekbzqu