The objective of the present study was to develop the oral sustained release tablets of Bupropion hydrochloride using combination of hydrophilic polymers. Bupropion Hydrochloride is a Anti-Depressant agent used in symptomatic treatment of depression, maniac, and smoking withdrawal conditions. FT-IR studies were carried to know the interaction, showed that absence of any interactions between the drug and polymers. Optimization of the formulation was done by studying effect of drug to polymer

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... o on drug release. The physicochemical properties of tablets were found within the limits. The drug release from optimized formulation BST-5 was extended for a period of about 12 h. The kinetic treatment to optimized formulations showed that the release of drug follows zero order model and Super Case II transport. Release of the drug was retarded with increase in polymer concentrations. The optimized formulations were subjected to stability studies for two months at 40±2 ºC temperature with RH 75±5 %, and showed stability with respect to physicochemical parameters and release pattern. Results of the present study indicated the suitability of hydrophilic polymers in the preparation of sustained release formulation of Bupropion hydrochloride.