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Alternative splicing is a key step in eukaryotic gene expression that allows the production of multiple protein isoforms from the same gene. Even though splicing is perturbed in many diseases, we currently lack insights into regulatory mechanisms promoting its precision and efficiency. Using mechanistic mathematical modeling, we show that alternative splicing control is facilitated if spliceosomes recognize exons as functional units (exon definition). We find that exon definition is crucial todoi:10.1101/714022 fatcat:rmo4ohv66ranhayp7dgdtm2gty