Trans [Co(en) 2 (CH 3 CH 2 CH 2 )H 2 o] 2+ :Synthesis, Characterization, Equilibria, Kinetics and DNA-Binding Studies

N Padmaja, Kotha Reddy, P Pallavi, Satyanarayana
Journal of Chemical and Pharmaceutical Research   unpublished
Pseudo first order reaction kinetics and binding studies of trans-[Co(en) 2 (CH 3 CH 2 CH 2)H 2 O] 2+ complex with imidazole ,substituted imidazoles, glycine and ethyl glycine ester has been investigated using spectrophotometric technique. Equilibrium constants were determined as a function of pH at 25°c. Binding and kinetic studies were correlated based on basicity, steric hindrance. From the equilibrium data, it is found that the entering nucleophile is participating in the transition state,
more » ... transition state, thereby SN 1 mechanism is proposed. The effect of the incoming ligands on the complex is studied by molecular mechanics. The interaction of trans-[Co(en) 2 (CH 3 CH 2 CH 2)H 2 O] 2+ with CT DNA has been studied spectrophotometrically.