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Evolving concepts of tumor heterogeneity
2014
Cell & Bioscience
Past and recent findings on tumor heterogeneity have led clinicians and researchers to broadly define cancer development as an evolving process. This evolutionary model of tumorigenesis has largely been shaped by seminal reports of fitness-promoting mutations conferring a malignant cellular phenotype. Despite the major clinical and intellectual advances that have resulted from studying heritable heterogeneity, it has long been overlooked that compositional tumor heterogeneity and tumor
doi:10.1186/2045-3701-4-69
pmid:25937891
pmcid:PMC4417538
fatcat:ki7wxdds5bg67e733gdwkjye2i