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p53 shades of Hippo
Cell Death and Differentiation
The three p53 family members, p53, p63 and p73, are structurally similar and share many biochemical activities. Yet, along with their common fundamental role in protecting genomic fidelity, each has acquired distinct functions related to diverse cell autonomous and non-autonomous processes. Similar to the p53 family, the Hippo signaling pathway impacts a multitude of cellular processes, spanning from cell cycle and metabolism to development and tumor suppression. The core Hippo module consistsdoi:10.1038/cdd.2017.163 pmid:28984872 fatcat:ou6vxb7aa5alrcz6efg5rpcrzy