Based on previous knowledge of other epidemics such as SARS, MERS and H1N1, it is proposed that pregnant women may have a severe clinical outcome in some situations. It is not different for COVID-19. The control of SARS-CoV-2 infection among pregnant women and their potential risk of vertical transmission are a concern to the medical and scientific community. However, the maternal organism does not behave the same way during those forty weeks. Here we show the differences in pathophysiology of

more »

... OVID-19 in pregnant women as a consequence of physiological and immunological changes related to each gestational period, in order to guide an appropriate therapy and care for this population. We observed that these women are in a transient physiological condition in which ACE-2 is highly expressed and, despite its protective mechanism for pregnancy, it is also used by the virus as a route of entry. Moreover, their physiological immunosuppression associated with cytokines increased levels, may lead to a cytokine storm, especially in the first trimester and at the end of pregnancy (pro-inflammatory stages). Therefore, we found in this review that individualization of each gestational period should be practiced not considering pregnancy as a unique status.