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The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle
Journal of Endocrinology
Experiments were conducted to test whether oestradiol (E2) protects granulosa cells from Fas ligand (FasL)-induced apoptosis and whether protection involves modulation of the cell cycle of proliferation. Treatment of cultured bovine granulosa cells with E2 decreased susceptibility to FasL-induced apoptosis. The effects of E2 were mediated through oestrogen receptor and were not mediated by stimulation of IGF production. E2 also increased the percentage of cells progressing from G1 to S phase ofdoi:10.1677/joe.1.06549 pmid:16731776 fatcat:o7i372vqkjemlirwu5l6gdbul4