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Growth and differentiation factor 15 causes skeletal muscle wasting in pulmonary arterial hypertension through actions on transforming growth factor β activated kinase 1
2018
Muscle wasting is an important complication of a wide range chronic diseases. Pulmonary arterial hypertension (PAH) is no different. Novel targets and treatments are required to help improve outcomes in patients with PAH complicated by muscle wasting. GDF-15 is prognostic marker in PAH and has been shown to cause muscle wasting in vitro and in vivo. The pathway through which GDF-15 acts in muscle cells is not established. I used a human study, animal models of PAH; the monocrotaline (MCT) rat;
doi:10.25560/59682
fatcat:mfwoqcpoyvbohazngc5wkjelle