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Brg1/SMARCA4 serves as the ATPase and the helicase catalytic subunit for the multicomponent SWI/SNF chromatin remodeling complex, which plays a pivotal role in governing chromatin structure and gene transcription. However, the upstream signaling pathways regulating Brg1 protein stability and its physiological contribution to carcinogenesis remain largely elusive. Here we report that Brg1 is a bona fide ubiquitin substrate of SCF FBW7 . We reveal that CK1δ phosphorylates Brg1 at Ser31/Ser35doi:10.1038/s41467-018-06038-y fatcat:4rsjtpeudfhefmq4qgdrfth4qa