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Modeling the functional consequences of single residue replacements in bacteriophage f1 gene V protein
2009
Protein Engineering Design & Selection
A computational mutagenesis methodology utilizing a four-body, knowledge-based, statistical contact potential is applied toward globally quantifying relative environmental perturbations (residual scores) in bacteriophage f1 gene V protein (GVP) due to single amino acid substitutions. We show that residual scores correlate well with experimentally measured relative changes in protein function upon mutation. Residual scores also distinguish between GVP amino acid positions grouped according to
doi:10.1093/protein/gzp050
pmid:19690089
fatcat:wzxj2hej3zcg5dl3g26ufmutgy