Extracting the Groupwise Core Structural Connectivity Network: Bridging Statistical and Graph-Theoretical Approaches [article]

Nahuel Lascano, Rachid Deriche
2017 arXiv   pre-print
Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuro-science. Recent evidence suggests there's a tightly connected network shared between humans. Obtaining this network will, among many advantages , allow us to focus cognitive and clinical analyses on common connections, thus increasing their statistical power. In turn, knowledge about the common network will facilitate novel analyses to understand the structure-function
more » ... lationship in the brain. In this work, we present a new algorithm for computing the core structural connectivity network of a subject sample combining graph theory and statistics. Our algorithm works in accordance with novel evidence on brain topology. We analyze the problem theoretically and prove its complexity. Using 309 subjects, we show its advantages when used as a feature selection for connectivity analysis on populations, outperforming the current approaches.
arXiv:1701.01311v3 fatcat:i3pee6kefvhpjoryllrkpzuoou