تأثير المستخلص المائي والکحولي للکرکديه والتمر هندي وخليطهم على وظيفة الکبد وصورة الدهون فى الفئران المصابه ببرومات البوتاسيوم
مجلة الاقتصاد المنزلي جامعة المنوفية
A study was conducted to investigate the effect of aqueous and alcoholic extracts of Roselle, Tamarind and their mixture on liver function and lipid profile in rats treated by potassium bromate. A total number of 40 mal albino rats were devided into 8 groups each of 5 rats, one of them served as control negative group, then remain groups of rats treated with potassium bromate (20mg/kg bw) orally intragastric twice a week for 4 weeks, one of them served as control positive group. Treatments
... up. Treatments groups received 40mg/kg bw daily of aqueous or alcoholic extracts of roselle, tamarind and their mixture during experimental period. Blood was collected and serum was used for measure serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total Protein, Albumin, Globulin, Triglycerides (TG), Total Cholesterol , HDL-c, LDL-c, and VLDL-c, also atherogenic index (AI) was calculated. The results showed that alcholic extract of tamarind and mixture showed perfect effect in the levels of ALP and ALT, whereas the good treatment in the level of AST found for aqueous and alcoholic extracts of mixture and alcholic tamarind extract which did not significantly different than normal rats. Extracts of roselle showed in levels of liver Enzymes non significant changes compared to control Positive group. Aqueous and alcoholic extracts of roselle, tamarind and their mixture led to significant increase 80 in HDL-cholesterol levels and decrease in levels of total cholesterol, LDL-c and VLDL-c. All extracts of treatments did not reveal any significant changes in Triglycerides, total cholesterol, VLDL-c and atherogenic index compared with normal rats. The highest increase in the plasma HDL-cholesterol levels recorded for roselle alcholic extract and aqueous of mixture extract. The perfect effect on lipid profile in general was recorded for aqueous and alcoholic extracts of mixture. It is worthing observed that there was no significant difference between aqueous and alcoholic extracts in each type of tested plants and their mixture, which refer to the good effect of aqueous extracts. In conclousion mixture of roselle and tamarind serve as a good cholice for health effects on liver function and lipid profile. More studies were needed to detect the perfect and safe dose of these plants to use in human. Khandare , A.L.; Kumar, U.; Shanker, R.G.; Venkaiah, K. and Lakshmaiah, N. (2004): Additional beneficial effect of tamarind ingestion over defluoridated water supply. Nutr., 20: 433-436. Khanzada, S.K.; Shaikh, W.; Sofia, W.; Kazi, T.; Usmanghani, K.; Kabir, A. and Sheerazi, T.H. (2008): Chemical constituents of tamarindus indica. Medicinal plant in sindh; Pak. J. Bot., 40(6): 2553-2559. Kobayashi, A.; Adenan, M.L.; Kajiyama, S.I.; Kanzaki, H. and Kawazu, K. (1996): A cytotoxic principle of Tamarindus indica, di-n-butyl malate and the structure-activity relationship of its analogues. J. Bio Sci., 51:233-42. Kolawole, S.O.; Kolawole, O.T. and Akanji, M. A. (2011): Effects of aqueous extract of Khayasenegalensis stem bark on biochemical and hematological parameters in rats. Journal of Pharmacology and Toxicology., 6 (6): 602-607. Kolawole, O. T.; Akiibinu, M. O. and Akanji, M. A . (2014): Assessment of the effect of aqueous extract of calyx of Hibiscus sabdariffa on some biochemical indices of renal function in rats. Int J Pharma Sci., 4(3): 587-590 . Komutarin, T.; Azadi, S.; Butterworth, L.; Keil, D.; Chitsomboon, B.; Suttaji, M. and Meade, B.J. (2004): Extract of the seed coat of Tamarindus indica exhibits nitric oxide production by murine microphages in vitro and in vivo. Food Chem. Toxicol., 42: 649-658. Landi Librandi, A.P.; Chrysóstomo, T.N.; Azzolini, A.E.; Recchia, C.G.; Uyemura, S.A. and de Assis-Pandochi, A.I. (2007): Effect of the extract of Tamarind fruit of the complement system: Studies in-vitro and in hamsters submitted to a cholesterolenriched diet. Food Chem Toxicol., 45:1487-95. Lin,W.L.; Hsieh, Y.J.; Chou, F.P.; Wang, C.J.; Cheng, M.T. and Tseng, T.H. (2003): Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage. Arch Toxicol.,77(1):42-47. Maiti, R.; Jana, D.; Das, U.k. and Hosh, D. (2004): Antidiabetic effect of aqueous extract of seed of Tamarindus indica L. in streptozotozin-induced diabetic rats. J. Ethnopharma., 92:85-91.