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NDRG2 Expression Increases Apoptosis Induced by Doxorubicin in Malignant Breast Caner Cells
Biomolecules & Therapeutics
N-myc downstream-regulated gene 2 (NDRG2) has recently been found to be a tumor suppressor gene. Although it has been reported that NDRG2 expression in breast cancer cells decreases cell proliferation by inhibiting STAT3 activation via SOCS1 induction, the molecular mechanism of chemotherapeutic agent-induced apoptosis is not well known. To elucidate the effect of NDRG2 on the apoptotic pathway induced by doxorubicin, we established stable cell lines expressing NDRG2 and investigated the effectdoi:10.4062/biomolther.2009.17.4.370 fatcat:vyqvro7cxnd3zdkydeqeo3rwdq