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Secondary structure alone is generally not statistically significant for the detection of noncoding RNAs
Motivation: Several results in the literature suggest that biologically interesting RNAs have secondary structures that are more stable than expected by chance. Based on these observations, we developed a scanning algorithm for detecting noncoding RNA genes in genome sequences, using a fully probabilistic version of the Zuker minimumenergy folding algorithm. Results: Preliminary results were encouraging, but certain anomalies led us to do a carefully controlled investigation of this class ofdoi:10.1093/bioinformatics/16.7.583 pmid:11038329 fatcat:ppdhf54obvf4lp2yweiwo7bq54