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RUNX3Inactivation by Point Mutations and Aberrant DNA Methylation in Bladder Tumors
RUNX3 is inactivated at high frequency in many tumors. However, in most cases, inactivation is caused by silencing of the gene due to promoter hypermethylation. Because epigenetic silencing is known to affect many major tumor suppressor genes in cancer cells, it is not clear whether RUNX3 is primarily responsible for the induction of carcinogenesis in these cases, except for the gastric cancer cases that we reported previously. We investigated genetic and epigenetic alterations of RUNX3 in 124doi:10.1158/0008-5472.can-05-1647 pmid:16230397 fatcat:ashrvmxqejfrbd5fxvjdfxus2y