COMPARATIVE EFFICACY OF ENZYME MEDICATION WITH THROMBOLYTIC EFFECT IN ATRIUM THROMBOSIS AND SPONTANEOUS ECHO-CONTRAST PHENOMENON IN PATIENTS WITH ATRIAL FIBRILLATION

E. V. Vyshlov, R. E. Batalov, V. A. Markov, S. V. Popov
2015 Russian Journal of Cardiology  
Aim. To assess efficacy of Thrombovazim ® in combination antithrombotic therapy in atrial fibrillation (AF) with intra-atrial clots of spontaneous echo-contrasting found by echocardiography. Material and methods. Totally 28 patients included with persisting atrial fibrillation: 20 with thrombosis of the left atrium appendage and 8 with the phenomenon of spontaneous echo-contrasting of II-III grate in atrium by transesophageal ultrasound contrast study (TEECS). Among patients with left appendage
more » ... thrombosis there were 15 men and 5 women, mean age 60,3±1,6. Among those with spontaneous echocontrasting -4 men and 4 women, mean age 58,2±1,2. After detecting the thrombus or spontaneous echo-contrasting phenomenon all patients were prescribed Thrombovazim ® in dosage 800U t. i.d. for 7 days with standard warfarin therapy. Results. On the control TEECS at the 8th day of therapy among 20 patients with previously diagnosed left appendage thrombosis in 19 were found the absence of clots. Level of total fibrinogen and soluble fibrin-monomers complexes in Thrombovazim ® intake did not change. In all patients with spontaneous echocontrasting phenomenon after Thrombovazim ® course this phenomenon still existed, so Thrombovazim ® was not effective in this phenomenon elimination. There were no side effects of Thrombovazim ® . Conclusion. In atrial fibrillation patients and thrombus in left atrium appendage the use of Thrombovazim ® 800U t. i.d. per os at the background of standard therapy by warfarin during 7 days in 95% leads to the lysis of clots without side effects. In spontaneous echo-contrasting phenomenon in atrial fibrillation Thrombovazim ® 800U t. i.d. per os with standard therapy for 7 days does not lead to this phenomenon elimination. The lack of effect of Thrombovazim ® in the phenomenon of spontaneous echo-contrasting indirectly suggests that there are not fibrin strands in this phenomenon. Russ J Cardiol 2015, 9 (125): 71-75 http://dx.
doi:10.15829/1560-4071-2015-9-71-74 fatcat:rhjivhvwp5dsraiuf3gswwxmyi