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Folding kinetics of proteins with multiple domains: inference of transition rates from extinction times
Journal of Physics Communications
In this paper we are concerned with the folding kinetics of large proteins that may have multiple binding/unbinding domains. The theory underlying such systems have received much less attention compared to small, 'two-state' (folded/unfolded) proteins. To analyze this problem, we model the reaction coordinate using a birth-death chain, a well-known stochastic process. Specifically, we consider a protein with N domains where every domain that unfolds (folds) increases (decreases) the reactiondoi:10.1088/2399-6528/aacca5 fatcat:mlmpd4szwrgu7owcm7i6y42qpq