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The aim of this study is to show the effects of agmatine, which is shown to be promising as a preventive (neuroprotective) agent on glutamate induced neuron damage in newborn rat brain cortex. The newborn 4 rats were rapidly decapitated and the cortex were taken surgically and stored immediately in the prepared neurobasal solution. Low doses of agmatine prevent cell death against glutamate and have a stronger neuroactive effect. Increased TOC level and decreased TAC level were significantlydoi:10.5281/zenodo.2542624 fatcat:ht24tqss4zeuzecawcwuu3ygje