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The involvement of senescence induced by the telomere shortness in the decline of osteogenic differentiation in BMSCs
2017
European Review for Medical and Pharmacological Sciences
unpublished
OBJECTIVE: BMSC (Bone marrow mesenchymal stem cells) is an important seed cell for the repair of bone and cartilage defect in the tissue engineering. The proliferation rate and differentiation capacity of BMSCs from the old donors were less than that from young donors; however, the related mechanism remained unclear. MATERIALS AND METHODS: Sprague Daw-ley (SD) rats BMSCs were cultured and treated. Hydrogen peroxide (H 2 O 2) and continual passage of BMSCs were performed to induce se-nescence.
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