ANTI-INFLAMMATORY ACTIVITIES OF VICIA CANESCENCE AND VICIA HIRSUTA AERIAL PARTS

M Mahmoudi, M Hosseini, A Allami, M Ebrahimzadeh
2016 Archives •   unpublished
Many pharmacological activities have been reported in Papilionaceae family. The aim of present study was to investigate anti-inflammatory activities of Vicia canescence and Vicia hirsuta aerial parts. Inhibition of carrageenan induced edema was used to evaluate anti-inflammatory activity. The effect was dose-dependent. At all tested doses, extract produced statistically significant inhibition of inflammation when compared to the control group. V. canescence extract was more potent than V.
more » ... e extract (88.1 vs. 86.8% inhibition at 800 mg kg-1 i.p.) but no statistically difference was observed between them (p>0.05). V. canescence extract at 200 mg kg-1 (62.8%) and V. hirsute extract at 400 mg kg-1 (67.7%) were equipotent with diclofenac (p>0.05). Extracts were safe and did not exhibit any toxicity up to 3 g kg-1. This study indicates the potential therapeutic uses of V. canescence and V. hirsuta as potent antiinflammatory agents.
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