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The article presents a brief but comprehensive review of the large variety of mathematical models of drug controlled release from polymeric monoliths in the last 25 years. The models are considered systematically, from the first simple empirical models up to the most comprehensive theoretical ones taking into account the main release mechanisms (diffusion, swelling, dissolution or erosion) simultaneously. Their advantages and limitations are briefly discussed and some applications are outlined.doaj:a399a9928f8341c4b185211a9ae017e1 fatcat:iczr3t4k45btjj5x6horgdxn6y